Total price:
$101.75
New
PE-22-28-10mg
$101.75
PE-22-28 (N-hexanoic-Tyr-D-Ala-Gly-Phe-D-Lys-NH2)
PE-22-28 is a synthetic peptide that has garnered significant research interest for its potential neurotrophic and antidepressant-like properties. It is a derivative of the naturally occurring human peptide spadin, which is found in human plasma and has a role in regulating the activity of the Two-Pore-Domain Potassium (K2P) channel TREK-1. PE-22-28 is a more stable and potent analog designed to enhance its bioavailability and optimize its pharmacological effects within the central nervous system. Its targeted action on specific neuronal pathways positions it as a promising candidate for investigations into mood disorders and neurodegenerative conditions.
Description
Quick Facts
PE-22-28 is a cutting-edge synthetic peptide, consisting of a 7-amino-acid sequence derived from spadin, a naturally occurring peptide from sortilin. Renowned for its high-affinity inhibition of the TREK-1 potassium channel, PE-22-28 is a powerful tool for researchers exploring neuroprotection, mood regulation, and cognitive enhancement. Supplied as a lyophilized powder in a 10mg vial, this peptide offers exceptional purity (≥99%) and stability, making it ideal for rigorous neuroscience and psychiatric research applications.
Key Features
- High Purity: Verified at ≥99% purity through advanced HPLC analysis, ensuring consistent and reliable results.
- Stable Formulation: Lyophilized for long-term stability when stored at -20°C, preserving its integrity for extended research.
- Targeted Mechanism: Acts as a potent TREK-1 inhibitor with an IC50 of 0.12 nM, offering superior specificity compared to spadin (40–60 nM).
- Versatile Applications: Supports studies in neurogenesis, mood disorders, and neuroprotection, addressing critical areas of neurological health.
Research Benefits
PE-22-28 is designed to modulate TREK-1 channels, which regulate neuronal excitability in key brain regions like the prefrontal cortex, amygdala, and hippocampus. Its research benefits include:
- Antidepressant Effects: Demonstrates rapid-onset antidepressant properties, reducing depressive-like behaviors in mouse models within days, unlike traditional antidepressants.
- Neurogenesis and Synaptogenesis: Promotes neuron growth and synaptic plasticity, increasing PSD-95 expression in cortical neurons, which supports cognitive health.
- Stroke Recovery: Enhances post-stroke recovery by reducing depressive behaviors and improving motor and cognitive deficits.
- Neuroprotection: Protects neurons from excitotoxicity and oxidative stress, potentially aiding in the study of neurodegenerative diseases like Alzheimer’s.
- Mood and Cognitive Enhancement: May improve memory, learning, and focus by modulating neurotransmitter pathways, offering insights into cognitive function.
Applications
PE-22-28 is ideal for laboratory investigations into:
- Rapid-onset antidepressant mechanisms and mood stabilization.
- Hippocampal neurogenesis and synaptic plasticity pathways.
- Neuroprotection and recovery following ischemic stroke or traumatic brain injury.
- TREK-1 channel interactions and their role in neurological and psychiatric disorders.
Usage and Storage
Supplied as a white lyophilized powder, PE-22-28 requires reconstitution with bacteriostatic water (not included) for research use. Store at -20°C to maintain stability. This product is intended solely for in-vitro studies and is not for human or animal consumption, adhering to strict laboratory research protocols.
Why Choose PE-22-28?
PE-22-28 stands out for its rapid effects, high specificity, and broad research potential. Its ability to influence mood, cognition, and neuroprotection without addictive effects or withdrawal symptoms makes it a valuable asset for advancing neuroscience research.
⚠️ *Important Notice: All peptides are supplied in a powdered (lyophilized) form. They must be reconstituted before use.
